Abstract | OBJECTIVE: DESIGN: This prospective, randomized, double-blind clinical trial included 99 patients (120 median nerves) with clinical and electrophysiologic evidence of CTS. The 120 median nerves were randomly assigned to one of three groups: group 1 received 40 mg of triamcinolone acetonide, group 2 received 4 ml of 1% procaine HCl, and group 3 received both 40 mg of triamcinolone acetonide and 4 ml of 1% procaine HCl. Clinical and electrophysiologic evaluations were performed at the study onset and at 2 and 6 mos after treatment. RESULTS: At the study onset, there were no statistically significant differences between the groups with respect to distal motor latency, compound motor action potential, compound sensory action potential, sensory nerve conduction velocity, or visual analog scale score; however, distal motor latency, compound sensory action potential amplitude, sensory nerve conduction velocity, and visual analog scale scores improved significantly in each group 2 mos after treatment (P < 0.05), and these improvements persisted at 6 mos after treatment (P < 0.05). Significant differences were not observed between groups 1 and 2 or between groups 1 and 3 with respect to electrophysiologic findings at baseline or 2 or 6 mos after treatment (P > 0.05). Group 3 had better compound sensory action potential amplitude and sensory nerve conduction velocity scores than group 2 did at 6 mos (P < 0.05) and better visual analog scale scores than group 2 did at 2 and 6 mos (P < 0.05). CONCLUSIONS: Local procaine HCl injection and steroid injection effectively reduced the symptoms of CTS and equally improved electrophysiologic findings. As such, procaine HCl can be used in CTS patients in whom steroid use is contraindicated.
|
Authors | Omer Karadaş, Fatih Tok, Umit Hidir Ulaş, Zeki Odabaşi |
Journal | American journal of physical medicine & rehabilitation
(Am J Phys Med Rehabil)
Vol. 90
Issue 4
Pg. 287-92
(Apr 2011)
ISSN: 1537-7385 [Electronic] United States |
PMID | 21273900
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Anesthetics, Local
- Glucocorticoids
- Procaine
- Triamcinolone Acetonide
|
Topics |
- Adult
- Anesthetics, Local
(therapeutic use)
- Carpal Tunnel Syndrome
(drug therapy)
- Cohort Studies
- Double-Blind Method
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Injections
- Male
- Middle Aged
- Procaine
(therapeutic use)
- Treatment Outcome
- Triamcinolone Acetonide
(therapeutic use)
|