Abstract | OBJECTIVE: STUDY DESIGN: Paired maternal and umbilical cord blood samples were collected at the time of delivery and the serum stored at -86°C. For each paired sample of maternal and cord blood, the medical chart and vaccine history was reviewed to determine whether Tdap was received or not. RESULTS: Newborns born from mothers who received Tdap during pregnancy had significantly higher concentrations of diphtheria antitoxin (P < .001), tetanus antitoxin (P = .004), and antibodies to pertussis toxin (P < .001), filamentous hemagglutinin (P = .002), pertactin (P < .001), and fimbriae 2/3 (P < .001) when compared to newborns from mothers who did not receive Tdap. There was a significant increase in the odds that newborns from mothers who received Tdap during pregnancy have antibodies that may provide protection against diphtheria (P = .0141), pertussis toxin (P < .0001), and fimbriae 2/3 (P = .0146). CONCLUSION:
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Authors | Stanley A Gall, John Myers, Michael Pichichero |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 204
Issue 4
Pg. 334.e1-5
(Apr 2011)
ISSN: 1097-6868 [Electronic] United States |
PMID | 21272845
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Mosby, Inc. All rights reserved. |
Chemical References |
- Adhesins, Bacterial
- Antibodies
- Bacterial Outer Membrane Proteins
- Diphtheria Antitoxin
- Diphtheria-Tetanus-Pertussis Vaccine
- Tetanus Antitoxin
- Virulence Factors, Bordetella
- filamentous hemagglutinin adhesin, Bordetella pertussis
- Fimbriae Proteins
- pertactin
- Pertussis Toxin
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Topics |
- Adhesins, Bacterial
(immunology)
- Antibodies
(blood)
- Bacterial Outer Membrane Proteins
(immunology)
- Diphtheria Antitoxin
(blood)
- Diphtheria-Tetanus-Pertussis Vaccine
- Female
- Fimbriae Proteins
(immunology)
- Humans
- Infant, Newborn
(blood)
- Pertussis Toxin
(immunology)
- Pregnancy
- Tetanus Antitoxin
(blood)
- Virulence Factors, Bordetella
(immunology)
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