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Maternal immunization with tetanus-diphtheria-pertussis vaccine: effect on maternal and neonatal serum antibody levels.

AbstractOBJECTIVE:
We sought to determine whether tetanus-diphtheria-pertussis vaccination (Tdap) in pregnancy provides newborns antibodies against pertussis when compared to mothers who did not receive Tdap.
STUDY DESIGN:
Paired maternal and umbilical cord blood samples were collected at the time of delivery and the serum stored at -86°C. For each paired sample of maternal and cord blood, the medical chart and vaccine history was reviewed to determine whether Tdap was received or not.
RESULTS:
Newborns born from mothers who received Tdap during pregnancy had significantly higher concentrations of diphtheria antitoxin (P < .001), tetanus antitoxin (P = .004), and antibodies to pertussis toxin (P < .001), filamentous hemagglutinin (P = .002), pertactin (P < .001), and fimbriae 2/3 (P < .001) when compared to newborns from mothers who did not receive Tdap. There was a significant increase in the odds that newborns from mothers who received Tdap during pregnancy have antibodies that may provide protection against diphtheria (P = .0141), pertussis toxin (P < .0001), and fimbriae 2/3 (P = .0146).
CONCLUSION:
Administering Tdap during pregnancy increases antibody titers against diphtheria and pertussis antigens. Maternal Tdap may prevent neonatal pertussis infection.
AuthorsStanley A Gall, John Myers, Michael Pichichero
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 204 Issue 4 Pg. 334.e1-5 (Apr 2011) ISSN: 1097-6868 [Electronic] United States
PMID21272845 (Publication Type: Journal Article)
CopyrightCopyright © 2011 Mosby, Inc. All rights reserved.
Chemical References
  • Adhesins, Bacterial
  • Antibodies
  • Bacterial Outer Membrane Proteins
  • Diphtheria Antitoxin
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Tetanus Antitoxin
  • Virulence Factors, Bordetella
  • filamentous hemagglutinin adhesin, Bordetella pertussis
  • Fimbriae Proteins
  • pertactin
  • Pertussis Toxin
Topics
  • Adhesins, Bacterial (immunology)
  • Antibodies (blood)
  • Bacterial Outer Membrane Proteins (immunology)
  • Diphtheria Antitoxin (blood)
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Female
  • Fimbriae Proteins (immunology)
  • Humans
  • Infant, Newborn (blood)
  • Pertussis Toxin (immunology)
  • Pregnancy
  • Tetanus Antitoxin (blood)
  • Virulence Factors, Bordetella (immunology)

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