Abstract | OBJECTIVE: Analysis of the influence of portal hypertension on intestinal permeability in HIV-infected patients with hepatitis C virus (HCV)-related cirrhosis and of the prognostic significance of consequent macrophage activation. METHODS: RESULTS: Patients with decompensated cirrhosis show increased LBP levels compared with HIV-monoinfected patients. Patients with increased LBP concentration showed elevated soluble CD14, soluble tumour necrosis factor receptor 55 Kd, and IL-6 levels. Twenty-two patients died, from liver-related causes, during the follow-up, and 2 more underwent liver transplantation. Child-Pugh index, CD4 T-cell count, plasma aldosterone and serum IL-6 concentrations independently predicted liver-related mortality. CONCLUSIONS: Increased intestinal permeability, as measured by serum LBP levels, observed in patients with HIV infection is significantly higher in patients with decompensated liver cirrhosis. Proinflammatory cytokines (IL-6) are prognostic markers of HIV-HCV-coinfected patients with decompensated cirrhosis.
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Authors | Montserrat Montes de Oca Arjona, Mercedes Marquez, Maria Jose Soto, Claudio Rodriguez-Ramos, Alberto Terron, Antonio Vergara, Ana Arizcorreta, Clotilde Fernandez-Gutierrez, Jose Antonio Giron-González |
Journal | Journal of acquired immune deficiency syndromes (1999)
(J Acquir Immune Defic Syndr)
Vol. 56
Issue 5
Pg. 420-7
(Apr 15 2011)
ISSN: 1944-7884 [Electronic] United States |
PMID | 21266909
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acute-Phase Proteins
- Carrier Proteins
- IL6 protein, human
- Interleukin-6
- Membrane Glycoproteins
- lipopolysaccharide-binding protein
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Topics |
- Acute-Phase Proteins
- Adult
- Bacterial Translocation
(physiology)
- Carrier Proteins
(blood)
- Female
- HIV Infections
(complications, mortality, virology)
- HIV-1
- Hepacivirus
- Hepatitis C
(complications, mortality, virology)
- Humans
- Hypertension, Portal
(complications, mortality)
- Interleukin-6
(blood)
- Intestines
(microbiology)
- Liver Cirrhosis
(complications, mortality, physiopathology, virology)
- Macrophage Activation
- Male
- Membrane Glycoproteins
(blood)
- Middle Aged
- Permeability
- Prognosis
- Survival Analysis
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