In vitro susceptibility of Madurella mycetomatis to posaconazole and terbinafine.

Abstract

Presently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, the in vitro susceptibilities of 34 Madurella mycetomatis strains were determined. It appeared that posaconazole was highly active against M. mycetomatis but terbinafine was only moderately active. Since posaconazole has an excellent safety profile, it might provide an important alternative in mycetoma therapy.

• Authors: Alex van Belkum, Ahmed H Fahal, Wendy W J van de Sande
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 55 Issue 4 Pg. 1771-3 (Apr 2011) ISSN: 1098-6596 [Electronic] United States
• PMID: 21263050 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Naphthalenes
• Triazoles
• Itraconazole
• posaconazole
• Terbinafine
• Ketoconazole

Topics

• Antifungal Agents (pharmacology)
• Itraconazole (pharmacology)
• Ketoconazole (pharmacology)
• Madurella (drug effects)
• Microbial Sensitivity Tests
• Naphthalenes (pharmacology)
• Terbinafine
• Triazoles (pharmacology)