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Ezetimibe is effective in the treatment of persistent hyperlipidemia of renal allograft recipients.

AbstractINTRODUCTION:
Ezetimibe is a hypolipidemic agent acting via inhibition of cholesterol absorption from the small intestine. The effectiveness and safety of long-term administration of ezetimibe was evaluated in renal allograft recipients with persistent hyperlipidemia.
PATIENTS AND METHODS:
67 renal allograft recipients with post-transplantation hyperlipidemia resistant to statins were included in the study; 11 were treated with ezetimibe (10 mg/day) alone and 56 with ezetimibe and statin. The effectiveness of ezetimibe was assessed by determination of total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C) and triglycerides (TR). Its safety was determined by liver enzymes (ALT, AST), LDH, CPK, serum creatinine and blood levels of immunosuppressive drugs (cyclosporine, tacrolimus, everolimus, sirolimus) over the follow-up period of 18±6 months.
RESULTS:
A significant reduction of TC and LDL-C blood levels by 25% and 34% respectively, was observed during the first month of treatment with ezetimibe (p<0.001). This reduction was maintained for the whole period of ezetimibe administration. Renal function remained stable over the follow-up period, while no changes of the blood levels of immunosuppressive drugs were observed. Liver enzymes, LDH and CPK remained normal in all patients except for one diabetic patient who developed rhabdomyolysis. Apart from gastrointestinal symptoms in 2 patients, no other side effects were observed.
CONCLUSION:
Combination of ezetimibe with statins represents an effective and safe regimen for treatment of persistent hyperlipidemia in renal allograft recipients.
AuthorsE Savvidaki, M Koukoulaki, A Benou, M Roumeliotou, C Fourtounas, P Kalliakmani, E Papachristou, J G Vlachojannis, D Goumenos
JournalClinical nephrology (Clin Nephrol) Vol. 75 Issue 2 Pg. 107-12 (Feb 2011) ISSN: 0301-0430 [Print] Germany
PMID21255539 (Publication Type: Journal Article)
Chemical References
  • Anticholesteremic Agents
  • Azetidines
  • Biomarkers
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Immunosuppressive Agents
  • Cholesterol
  • Ezetimibe
Topics
  • Adult
  • Anticholesteremic Agents (adverse effects, therapeutic use)
  • Azetidines (adverse effects, therapeutic use)
  • Biomarkers (blood)
  • Cholesterol (blood)
  • Cholesterol, HDL (blood)
  • Cholesterol, LDL (blood)
  • Drug Resistance
  • Drug Therapy, Combination
  • Ezetimibe
  • Female
  • Greece
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects, therapeutic use)
  • Hyperlipidemias (blood, drug therapy, etiology)
  • Immunosuppressive Agents (blood, therapeutic use)
  • Kidney Transplantation (adverse effects)
  • Male
  • Middle Aged
  • Retrospective Studies
  • Time Factors
  • Transplantation, Homologous
  • Treatment Outcome

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