[Successful therapy of sacroiliitis in SAPHO syndrome by etanercept].

Abstract

Painful, aseptic osteitis remains the major problem in the treatment of patients with SAPHO syndrome. We present a child suffering of both sacroiliitis and acne conglobata in the context of SAPHO syndrome. While acne lesions responded well to systemic isotretinoin, sacroiliitis associated pain could be controlled neither by NSAR nor by intralesional or systemic steroid injection. Worse pain limited substantially patient's mobility. This changed immediately after starting etanercept. Within a few days, pain resolved and the patient regained his mobility. This favourable response lasted for 8 months when we tried to stop etanercept under protection with the DMARD sulfazalazin. Unfortunately, within a few days, pain and immobility re-occurred requiring reinstitution of etanercept. This case demonstrates that, similar to other reports, TNF blockade is able to induce prompt and long-lasting response of SAPHO syndrome associated osteoarthritis to TNF blockade.

• Authors: Carola Wolber, Karin David-Jelinek, Astrid Udvardi, Gottfried Artacker, Beatrix Volc-Platzer, Herbert Kurz
• Journal: Wiener medizinische Wochenschrift (1946) (Wien Med Wochenschr) Vol. 161 Issue 7-8 Pg. 204-8 (Apr 2011) ISSN: 1563-258X [Electronic] Austria
• Vernacular Title: Sacroileitis im Rahmen eines SAPHO Syndroms - promptes Ansprechen auf Etanercept.
• PMID: 21253816 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antirheumatic Agents
• Immunoglobulin G
• Receptors, Tumor Necrosis Factor
• Etanercept

Topics

• Acne Vulgaris (diagnosis, drug therapy)
• Acquired Hyperostosis Syndrome (diagnosis, drug therapy)
• Adolescent
• Antirheumatic Agents (adverse effects, therapeutic use)
• Austria
• Etanercept
• Humans
• Immunoglobulin G (adverse effects, therapeutic use)
• Magnetic Resonance Imaging
• Male
• Mobility Limitation
• Pain Measurement (drug effects)
• Receptors, Tumor Necrosis Factor (therapeutic use)
• Sacroiliitis (diagnosis, drug therapy)
• Spondylitis, Ankylosing (diagnosis, drug therapy)
• Turkey (ethnology)