Immunohistochemical and biomolecular identification of 5-HT₇ receptor in rat vestibular nuclei.

Abstract

The association between migraine and balance disorder morbidities has been a topic of interest for many years, and serotonin (5-HT) receptor is known to be closely related with migraine and also to be associated with vestibular symptoms. However, the mechanism underlying the pathogenesis of migrainous vertigo and its association with 5-HT has not been elucidated. Of the many 5-HT receptors, 5-HT₇ receptor has recently attracted attention in the context of migraine treatment. The purpose of this study was to investigate the localization and expression of 5-HT₇ receptor in the rat vestibular nuclei by immunohistochemical staining and reverse transcriptase-polymerase chain reaction (RT-PCR). The present study might provide additional insight into the role of 5-HT₇ receptor in the pathogenesis of migraine-related vestibular symptoms.

• Authors: Roza Khalmuratova, Young-Sool Hah, Seong-Ki Ahn, Sea-Yuong Jeon, Jin-Pyeong Kim, Carey D Balaban
• Journal: Journal of vestibular research : equilibrium & orientation (J Vestib Res) Vol. 20 Issue 6 Pg. 401-6 ( 2010) ISSN: 1878-6464 [Electronic] Netherlands
• PMID: 21248402 (Publication Type: Journal Article)

Chemical References

• 5-HT(7) receptor, rat
• RNA, Messenger
• Receptors, Serotonin

Topics

• Animals
• Immunohistochemistry
• Male
• Migraine Disorders (complications, etiology)
• Postural Balance
• RNA, Messenger (metabolism)
• Rats
• Rats, Sprague-Dawley
• Receptors, Serotonin (genetics, metabolism)
• Reverse Transcriptase Polymerase Chain Reaction
• Tissue Distribution
• Vestibular Diseases (etiology)
• Vestibular Nuclei (metabolism)