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Rapid analgesic onset of intra-articular hyaluronic acid with ketorolac in osteoarthritis of the knee.

AbstractOBJECTIVE:
The purpose of this study was to evaluate the efficacy of intra-articular ketorolac to improve intra-articular hyaluronic acid (HA) therapy in knee osteoarthritis with respect to the initiation of pain relief.
METHODS:
This study was designed as a single-blind study with a blinded observer and a 3-month follow-up. Forty-three patients with knee osteoarthritis were randomized to the ketorolac group (n=21) or the HA group (n=22). Ketorolac group members were given three weekly intra-articular injections of HA with ketorolac and then two weekly intra-articular injections of HA; and HA group members were given five weekly intra-articular HA injections. Visual analog scale (VAS), pain rating score (PRS) and adverse events were assessed at baseline and at 1st, 3rd, 5th, and 16th week after treatment commencement.
RESULTS:
Significant improvement regarding pain assessment tools was observed in the ketorolac group by the addition of ketorolac to HA as compared with the HA group within 16 weeks of follow-up (p < 0.05). In the ketorolac group, 5 of the 21 subjects developed focal post-injection knee pain for about 8 hours after injection.
CONCLUSION:
Intra-articular HA with ketorolac showed more rapid analgesic onset than intra-articular HA alone and did not induce any serious complications.
AuthorsSang Chul Lee, Dong-Wook Rha, Won Hyuk Chang
JournalJournal of back and musculoskeletal rehabilitation (J Back Musculoskelet Rehabil) Vol. 24 Issue 1 Pg. 31-8 ( 2011) ISSN: 1878-6324 [Electronic] Netherlands
PMID21248398 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Hyaluronic Acid
  • Ketorolac
Topics
  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects, therapeutic use)
  • Arthralgia (drug therapy, etiology)
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Humans
  • Hyaluronic Acid (administration & dosage, adverse effects, therapeutic use)
  • Injections, Intra-Articular
  • Ketorolac (administration & dosage, adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Osteoarthritis, Knee (complications, drug therapy)
  • Pain Measurement
  • Prospective Studies
  • Single-Blind Method
  • Treatment Outcome

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