Abstract | BACKGROUND: The 595-nm pulsed dye laser has been used for the treatment of benign epidermal pigmented lesions (EPLs), but there is a risk of inducing undesirable purpura with treatment. OBJECTIVE: To compare a 607-nm laser with a commercially-available 595-nm laser for the treatment of EPLs. MATERIALS AND METHODS: Monte-Carlo simulations were performed to characterize laser interaction with skin. Ten patients with EPLs were treated with a 607-nm study prototype laser and the 595-nm pulsed dye laser twice at 2- to 4-week intervals on the left or right side on a randomized basis. Study endpoints included clearance rate of lesions, side effects immediately after treatment and at final follow-up, and patient discomfort/ pain. RESULTS: Monte-Carlo simulations show that the 607-nm is absorbed more specifically by melanin than the 595-nm wavelength. Both lasers were effective in treatment of EPLs. The average degree of improvement overall was 41.2% with the 607-nm laser and 40% with the 595-nm laser. Patients reported less discomfort/ pain during treatment with the 607-nm laser. CONCLUSIONS: Our findings suggest that the 607-nm laser is safe and at least as effective as the 595-nm laser in treatment of EPLs. There was less patient discomfort/ pain during treatment using the 607-nm laser.
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Authors | Peggy L Chern, Yacov Domankevitz, E Victor Ross |
Journal | Lasers in surgery and medicine
(Lasers Surg Med)
Vol. 42
Issue 10
Pg. 705-9
(Dec 2010)
ISSN: 1096-9101 [Electronic] United States |
PMID | 21246573
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Wiley-Liss, Inc. |
Topics |
- Adult
- Aged
- Cohort Studies
- Epidermis
(radiation effects)
- Female
- Humans
- Hyperpigmentation
(pathology, radiotherapy)
- Lasers, Dye
(therapeutic use)
- Low-Level Light Therapy
- Middle Aged
- Models, Biological
- Pilot Projects
- Treatment Outcome
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