Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer.

Abstract

We evaluated immunohistochemically the expression profiles of metastasis-associated protein (MTA) 1 and their associations with lymph node metastasis in tonsil cancer. Immunohistochemical analysis of 43 tonsillar neoplasm tissues was performed using antibodies raised to MTA1. Depth of tumor invasion, lymph node metastasis, and clinical outcomes were assessed. Clinical N0 patients were divided into two groups: N0a, negative for MTA1; N0b, positive for MTA1. Occult node metastasis was reevaluated according to the revised clinical N staging system taking account of MTA1 expression. The expression rate of MTA1 was 41.9%. There was a significant correlation between the expression of MTA1 and lymph node metastasis (P = 0.034*). MTA1 had a sensitivity of 53.3% and a specificity of 84.6% for identification of cervical metastases. When cN0b patients were considered to be N+, the recalculated rate of occult metastasis fell from 50% to 7.6% (the false-positive rate remained unchanged). MTA1 was found to be a useful molecular marker to predict lymphatic metastasis in tonsil cancer.

• Authors: Jun-Ook Park, Chan-Kwon Jung, Dong-Il Sun, Young-Hoon Joo, Min-Sik Kim
• Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 268 Issue 9 Pg. 1329-34 (Sep 2011) ISSN: 1434-4726 [Electronic] Germany
• PMID: 21240515 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Mta1 protein, human
• Repressor Proteins
• Trans-Activators
• Histone Deacetylases

Topics

• Biomarkers, Tumor (metabolism)
• Biopsy, Needle
• Carcinoma, Squamous Cell (metabolism, mortality, pathology, secondary, surgery)
• Cohort Studies
• Disease-Free Survival
• Female
• Gene Expression Regulation, Neoplastic
• Histone Deacetylases (metabolism)
• Humans
• Immunohistochemistry
• Lymph Node Excision (methods)
• Lymphatic Metastasis
• Male
• Neck Dissection (methods)
• Neoplasm Staging
• Prognosis
• Repressor Proteins (metabolism)
• Retrospective Studies
• Risk Assessment
• Sensitivity and Specificity
• Survival Analysis
• Tonsillar Neoplasms (metabolism, mortality, pathology, surgery)
• Tonsillectomy (methods)
• Trans-Activators