Abstract | BACKGROUND/PURPOSE: METHODS: Data were collected retrospectively from 5 North American pediatric hospitals. Sixty-two children underwent partial splenectomy for hereditary spherocytosis between 1990 and 2008. RESULTS: At 1 year following partial splenectomy, mean hemoglobin significantly increased by 3.0 ± 1.4 g/dL (n = 52), reticulocyte count decreased by 6.6% ± 6.6% (n = 41), and bilirubin level decreased by 1.3 ± 0.9 mg/dL (n = 25). Patients with poor or transient hematologic response were found to have significantly more splenic regeneration postoperatively compared with patients with a durable clinical response (maximal spleen dimension, 9.0 ± 3.4 vs 6.3 ± 2.2 cm). Clinically significant recurrence of anemia or abdominal pain led to completion splenectomy in 4.84% of patients. No patients developed postsplenectomy sepsis. CONCLUSIONS:
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Authors | Keely L Buesing, Elisabeth T Tracy, Colleen Kiernan, Aimee C Pastor, Laura D Cassidy, J Paul Scott, Russell E Ware, Andrew M Davidoff, Frederick J Rescorla, Jacob C Langer, Henry E Rice, Keith T Oldham |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 46
Issue 1
Pg. 178-83
(Jan 2011)
ISSN: 1531-5037 [Electronic] United States |
PMID | 21238662
(Publication Type: Comparative Study, Journal Article, Multicenter Study)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adolescent
- Bilirubin
(blood)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Hospitals, Pediatric
(statistics & numerical data)
- Humans
- Infant
- Male
- Regeneration
(physiology)
- Reticulocyte Count
(statistics & numerical data)
- Spherocytosis, Hereditary
(blood, surgery)
- Spleen
(physiology)
- Splenectomy
(methods)
- Treatment Outcome
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