Abstract | BACKGROUND: Subcutaneous self-injection of medication has benefits for the patient and healthcare system, but there are barriers such as dexterity problems and injection anxiety that can prevent self-injection being used effectively. An accurate method of evaluating patients' experiences with self-injection would enable assessment of their success in giving self- injections and the likelihood of them adhering to a self-injection regimen. The aim of this study was to develop a questionnaire to measure overall patient experience with subcutaneous self-injection (the Self-Injection Assessment Questionnaire [SIAQ]), and to investigate its psychometric properties. METHODS: The construct validity and reliability of the SIAQ were tested in patients with rheumatoid arthritis who volunteered to inject certolizumab pegol using a standard syringe during an open-label multinational extension trial of the long-term safety and efficacy of this drug. The SIAQ PRE module was self-completed before the first self-injection, and the POST module was self-completed following each of three fortnightly self- injections. RESULTS: Ninety-seven patients completed the SIAQ. All items correlated well with their respective domains in confirmatory factor analysis. As predicted, compared with other participants, patients with very low scores (less than 3 out of 10) in PRE causal domains (Feelings about injections and Self-confidence) were significantly less satisfied with their first self-injection, as were patients with a very low score in any POST causal domain (Self-confidence, Feelings about injections, Injection-site reactions and Ease of use), demonstrating known-groups validity. Causal domain scores generally correlated most strongly with the Satisfaction with self-injection domain, supporting convergent validity. The SIAQ demonstrated internal consistency and reproducibility; Cronbach's α and the test-retest coefficient were > 0.70 for all domains. Sensitivity and responsiveness were also shown, where measurable. Each language version showed structural validity. CONCLUSION:
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Authors | Dorothy Keininger, Geoffroy Coteur |
Journal | Health and quality of life outcomes
(Health Qual Life Outcomes)
Vol. 9
Pg. 2
(Jan 13 2011)
ISSN: 1477-7525 [Electronic] England |
PMID | 21232106
(Publication Type: Journal Article, Validation Study)
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Chemical References |
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Topics |
- Adult
- Aged
- Antirheumatic Agents
(administration & dosage)
- Arthritis, Rheumatoid
(drug therapy, psychology)
- Factor Analysis, Statistical
- Female
- Humans
- Injections, Subcutaneous
- Male
- Middle Aged
- Psychometrics
(standards)
- Quality of Life
- Reproducibility of Results
- Self Administration
(psychology)
- Surveys and Questionnaires
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