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Assessment of self-injection experience in patients with rheumatoid arthritis: psychometric validation of the Self-Injection Assessment Questionnaire (SIAQ).

AbstractBACKGROUND:
Subcutaneous self-injection of medication has benefits for the patient and healthcare system, but there are barriers such as dexterity problems and injection anxiety that can prevent self-injection being used effectively. An accurate method of evaluating patients' experiences with self-injection would enable assessment of their success in giving self-injections and the likelihood of them adhering to a self-injection regimen. The aim of this study was to develop a questionnaire to measure overall patient experience with subcutaneous self-injection (the Self-Injection Assessment Questionnaire [SIAQ]), and to investigate its psychometric properties.
METHODS:
The construct validity and reliability of the SIAQ were tested in patients with rheumatoid arthritis who volunteered to inject certolizumab pegol using a standard syringe during an open-label multinational extension trial of the long-term safety and efficacy of this drug. The SIAQ PRE module was self-completed before the first self-injection, and the POST module was self-completed following each of three fortnightly self-injections.
RESULTS:
Ninety-seven patients completed the SIAQ. All items correlated well with their respective domains in confirmatory factor analysis. As predicted, compared with other participants, patients with very low scores (less than 3 out of 10) in PRE causal domains (Feelings about injections and Self-confidence) were significantly less satisfied with their first self-injection, as were patients with a very low score in any POST causal domain (Self-confidence, Feelings about injections, Injection-site reactions and Ease of use), demonstrating known-groups validity. Causal domain scores generally correlated most strongly with the Satisfaction with self-injection domain, supporting convergent validity. The SIAQ demonstrated internal consistency and reproducibility; Cronbach's α and the test-retest coefficient were > 0.70 for all domains. Sensitivity and responsiveness were also shown, where measurable. Each language version showed structural validity.
CONCLUSION:
The SIAQ was demonstrated to be a valid, reliable tool in patients with rheumatoid arthritis.
AuthorsDorothy Keininger, Geoffroy Coteur
JournalHealth and quality of life outcomes (Health Qual Life Outcomes) Vol. 9 Pg. 2 (Jan 13 2011) ISSN: 1477-7525 [Electronic] England
PMID21232106 (Publication Type: Journal Article, Validation Study)
Chemical References
  • Antirheumatic Agents
Topics
  • Adult
  • Aged
  • Antirheumatic Agents (administration & dosage)
  • Arthritis, Rheumatoid (drug therapy, psychology)
  • Factor Analysis, Statistical
  • Female
  • Humans
  • Injections, Subcutaneous
  • Male
  • Middle Aged
  • Psychometrics (standards)
  • Quality of Life
  • Reproducibility of Results
  • Self Administration (psychology)
  • Surveys and Questionnaires

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