Protective effects of plasma alpha-tocopherols on the risk of inorganic arsenic-related urothelial carcinoma.

Abstract

Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC.

• Authors: Chi-Jung Chung, Yeong-Shiau Pu, Ying-Ting Chen, Chien-Tien Su, Chia-Chang Wu, Horng-Sheng Shiue, Chao-Yuan Huang, Yu-Mei Hsueh
• Journal: The Science of the total environment (Sci Total Environ) Vol. 409 Issue 6 Pg. 1039-45 (Feb 15 2011) ISSN: 1879-1026 [Electronic] Netherlands
• PMID: 21227482 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Antioxidants
• Carcinogens, Environmental
• Guanine
• 8-oxo-7,8-dihydrodeoxyguanine
• 8-Hydroxy-2'-Deoxyguanosine
• alpha-Tocopherol
• Arsenic

Topics

• 8-Hydroxy-2'-Deoxyguanosine (analogs & derivatives)
• Antioxidants (metabolism)
• Arsenic (metabolism, toxicity, urine)
• Carcinogens, Environmental (metabolism, toxicity)
• Carcinoma (epidemiology, metabolism, prevention & control)
• Case-Control Studies
• DNA Damage
• Female
• Guanine (analogs & derivatives, metabolism, urine)
• Humans
• Linear Models
• Male
• Middle Aged
• Multivariate Analysis
• Oxidative Stress (drug effects)
• Risk Factors
• Urologic Neoplasms (epidemiology, metabolism, prevention & control)
• alpha-Tocopherol (metabolism)