[A long-term survival case of bilateral ovarian metastasis of progressive gastric cancer treated by chemotherapy].

Abstract

We report a long-term survival case treated by chemotherapy with new anticancer drugs such as S-1, CPT-11 and docetaxel after bilateral overiectomy for bilateral ovarian metastases of progressive gastric cancer. A 68-year-old female, who had undergone total gastrectomy with D2 lymphadenectomy for scirrhous gastric cancer of Stage IIIA, was admitted because of ovarian metastasis. Laparoscopic bilateral ovariectomy was performed for ovarian metastases of the gastric cancer (Krukenberg tumor) 6 months after gastrectomy. Seven months after gastrectomy, 11-course of S-1 treatment (80 mg/m2) for bilateral ovarian metastases of the gastric cancer was administered. CT scan revealed mediastinal lymphadenopathy 2 years and 5 months after gastrectomy. Then, the drug was changed to docetaxel (60 mg/m2). After 9-course of docetaxel treatment, the mediastinal lymphadenopathy disappeared. For a treatment of grade 3 neuropathy, a 12-course CPT-11 was started after gastrectomy 3 years and 6 months ago. CT scan and PET-CT showed no new metastasis in 4 years and 10 months after gastrectomy.

• Authors: Hiroshi Sasaki, Fumitsugu Idani, Shinya Asami, Satoshi Komoto, Tetsushi Kubota, Kenjiro Kumano, Yohei Kurose, Shinichiro Kubo, Hiroki Nojima, Takashi Yoshioka, Masahiko Muro, Hitoshi Kin, Norihisa Takakura
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 12 Pg. 2478-80 (Nov 2010) ISSN: 0385-0684 [Print] Japan
• PMID: 21224612 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Antineoplastic Agents
• Antineoplastic Agents, Phytogenic
• Drug Combinations
• Taxoids
• S 1 (combination)
• Tegafur
• Docetaxel
• Oxonic Acid
• Irinotecan
• Camptothecin

Topics

• Adenocarcinoma, Scirrhous (pathology)
• Aged
• Antimetabolites, Antineoplastic (administration & dosage)
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Camptothecin (administration & dosage, analogs & derivatives)
• Docetaxel
• Drug Combinations
• Female
• Gastrectomy
• Humans
• Irinotecan
• Krukenberg Tumor (drug therapy, secondary)
• Ovarian Neoplasms (drug therapy, secondary)
• Ovariectomy
• Oxonic Acid (administration & dosage)
• Stomach Neoplasms (pathology)
• Taxoids (administration & dosage)
• Tegafur (administration & dosage)