I-123 MIBG scintigraphy and 68Ga-DOTANOC PET/CT negative but F-18 DOPA PET/CT positive pheochromocytoma: a case report.

Abstract

We observed a 34-year-old man who was incidentally found to have an adrenal mass during surgical follow-up for perforated ulcer. The patient was subjected to I-123 MIBG scintigraphy, 68Ga-DOTANOC PET/CT, and F-18 DOPA PET/CT. Only F-18 DOPA PET/CT showed evidence of an avid adrenal mass. A CT-guided biopsy was performed and it was suggestive for pheochromocytoma. He underwent surgery and a pheochromocytoma, about 40 mm in diameter, was detected. Traditionally, I-123 MIBG scintigraphy has been used in detecting chromaffin cell tumors, but more recently it had been demonstrated that a certain part of pheochromocytoma could be false-negative on scintigraphy.

• Authors: Ilaria Grassi, Cristina Nanni, Valentina Vicennati, Paolo Castellucci, Vincenzo Allegri, Gian Carlo Montini, Uberto Pagotto, Guido di Dalmazi, Renato Pasquali, Stefano Fanti
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 36 Issue 2 Pg. 124-6 (Feb 2011) ISSN: 1536-0229 [Electronic] United States
• PMID: 21220975 (Publication Type: Case Reports, Journal Article)

Chemical References

• 68Ga-DOTANOC
• Organometallic Compounds
• fluorodopa F 18
• 3-Iodobenzylguanidine
• Dihydroxyphenylalanine

Topics

• 3-Iodobenzylguanidine
• Adrenal Gland Neoplasms (diagnostic imaging, pathology, physiopathology)
• Adult
• Dihydroxyphenylalanine (analogs & derivatives)
• False Negative Reactions
• Humans
• Male
• Organometallic Compounds
• Pheochromocytoma (diagnostic imaging, pathology, physiopathology)
• Positron-Emission Tomography (methods)
• Tomography, X-Ray Computed (methods)