Effective analgesic between acetominophen + B vitamins vs. acetominophen in pediatric ambulatory surgery.

Abstract

BACKGROUND:

analgesics in pediatric ambulatory surgery must be safe and effective. Acetominophen is safe with moderate efficacy; therefore, we searched for other drugs. In preclinical trials, improved efficacy was reported with the combination of acetaminophen + B vitamins. The aim of this study was to determine the analgesic efficacy of acetaminophen + B vitamins in pediatric ambulatory surgery.

METHODS:

we conducted a clinical, comparative, randomized, double-blind study. We included 56 patients who were divided into four groups of 14 patients for each surgery (circumcision, tonsillectomy, inguinal hernioraphy, orchiopexy). Half of the patients received acetaminophen + B vitamins, and the remaining patients received acetaminophen alone. Variables were drugs, visual analogue scale and time of discharge. χ(2), Student t-test and analysis of variance (ANOVA) were used for statistical analysis.

RESULTS:

in children who received acetaminophen + B vitamins during the immediate postoperative period, 58% had a pain score <2 and 89% were discharged with a pain score %lt;1. Both schedules were effective and safe but acetaminophen + B vitamins showed a better pain score.

CONCLUSIONS:

the adjuvant effect of B vitamins was demonstrated with a better pain score in the immediate postoperative period and at the time of discharge.

• Authors: Alfonso Galván-Montaño, Gerardo Reyes-García, María de Lourdes Suárez-Roa, Juan Asbun-Bojalil
• Journal: Cirugia y cirujanos (Cir Cir) 2010 Sep-Oct Vol. 78 Issue 5 Pg. 400-9 ISSN: 2444-054X [Electronic] Mexico
• PMID: 21219810 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics, Non-Narcotic
• Vitamin B Complex
• Acetaminophen

Topics

• Acetaminophen (therapeutic use)
• Ambulatory Surgical Procedures
• Analgesics, Non-Narcotic (therapeutic use)
• Child
• Child, Preschool
• Double-Blind Method
• Drug Therapy, Combination
• Female
• Humans
• Male
• Pain, Postoperative (drug therapy)
• Prospective Studies
• Vitamin B Complex (therapeutic use)