Abstract |
Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR4 antigen and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Studies in English-language articles were identified by a search of PubMed and Embase database (inception to June 2010). A total of 19 case-control studies including 1378 cases and 10,383 controls provided data on the association between HLA-DR4 antigen and genetic susceptibility to IDC. Overall, statistically elevated frequency of HLA-DR4 allele [OR (odds ratio), 1.58; 95% CI (confidence interval), 1.21-2.07; P = 0.0009] was found in patients with IDC compared with controls. When stratified by myocardial biopsy or non-biopsy cases, statistically increased risks were found for IDC in both subgroups. In the subgroup analysis by ethnicity, significantly increased risk was found among Europeans from 12 case-control studies (OR, 1.54; 95% CI, 1.11-2.12; P = 0.009). In conclusion, our results suggest that HLA-DR4 antigen is a low-penetrant risk factor for developing IDC in Europeans.
|
Authors | B Jin, H Ni, Q Geshang, Y Li, W Shen, H Shi |
Journal | Tissue antigens
(Tissue Antigens)
Vol. 77
Issue 2
Pg. 107-11
(Feb 2011)
ISSN: 1399-0039 [Electronic] England |
PMID | 21214522
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
|
Copyright | © 2010 John Wiley & Sons A/S. |
Chemical References |
|
Topics |
- Cardiomyopathy, Dilated
(genetics, immunology)
- Case-Control Studies
- Genetic Predisposition to Disease
- HLA-DR4 Antigen
(genetics, immunology)
- Histocompatibility Testing
- Humans
- Risk Factors
|