An enucleated duodenal gastrinoma with multiple type 1 endocrine neoplasia located by selective arterial calcium injection.

Abstract

We report a duodenal gastrinoma in a 50-year-old man who was admitted to our hospital with tarry stools. Esophagogastroduodenoscopy revealed multiple ulcers in the duodenal bulb and a submucosal tumor in the descending duodenum. His serum gastrin level was 1400pg/ml. We suspected Zollinger-Ellison syndrome and performed selective arterial calcium injection to locate the gastrinoma. Increase in the hepatic venous gastrin level was seen only in the gastroduodenal artery area. We diagnosed a gastrinoma located in the pancreaticoduodenal area. Genetic examination showed a single-base deletion in the MEN-1 gene. At operation, the tumor was found in the submucosal layer of the descending duodenum and was extirpated. He is alive without recurrence 3 years after surgery.

• Authors: Hirokazu Shoji, Michio Kuroki, Eriko Nakano, Keiichiro Hiramoto, Yoshifumi Matsumura, Atsushi Miura, Yoshifumi Kikuchi, Hidetoshi Hirakawa, Mikio Matsuda
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 108 Issue 1 Pg. 80-7 (Jan 2011) ISSN: 0446-6586 [Print] Japan
• PMID: 21212598 (Publication Type: Case Reports, Journal Article)

Chemical References

• Calcium Gluconate

Topics

• Calcium Gluconate (administration & dosage)
• Duodenal Neoplasms (complications, diagnostic imaging, surgery)
• Gastrinoma (complications, diagnostic imaging, surgery)
• Humans
• Injections, Intra-Arterial
• Male
• Middle Aged
• Multiple Endocrine Neoplasia Type 1 (complications)
• Radiography