Abstract | OBJECTIVE: METHODS: Multicenter clinical trial. Asthenopia patients were chosen from eleven hospitals cross China from July, 2008 to January, 2009. The experiment was conducted asthenopia patients who used the Esculin and Digitalis glycosides Eye Drops for 4 weeks continuously. Symptoms of asthenopia, UCVA (uncorrected vision acuity), refraction, amplitude of accommodation, accommodative lag, accommodative sensitivity and positive/negative relative accommodation were measured at different time points, such as treated before, 1 week and 4 week in treated after. RESULTS: After the 4-week's use of Esculin and Digitalis glycosides Eye Drops, each subjective symptom of the patients was decreased significantly (F=353.30, P<0.05). In addition, most of the objective exams of accommodation ability were significantly improved, such as UCVA (left eye: F=23.39, P<0.05; right eye: F=15.62, P<0.05), refraction (left eye: F=10.34, P<0.05; right eye: F=17.13, P<0.05), amplitude of accommodation (left eye: F=14.46, P<0.05; right eye: F=8.29, P<0.05; eyes: F=13.86, P<0.05), accommodative lag (F=14.89, P<0.05) and accommodative sensitivity (left eye: F=62.67, P<0.05; right eye: F=68.77, P<0.05; eyes: F=82.74, P<0.05). And no patient appeared any adverse reaction in whole experiment. CONCLUSIONS:
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Authors | Zhen-ying Jiang, Xiao-mei Qu, Xiao-xin Li, Yu-ling Liu, Nian-ci Shen, Lin Zhang, Bi-lian Ke, Pei-quan Zhao, Jun Jiang, Ke Yao, Jin Zeng, Xiao Yang, Ren-yuan Chu |
Journal | [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
(Zhonghua Yan Ke Za Zhi)
Vol. 46
Issue 12
Pg. 1099-103
(Dec 2010)
ISSN: 0412-4081 [Print] China |
PMID | 21211224
(Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
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Chemical References |
- Digitalis Glycosides
- Ophthalmic Solutions
- Esculin
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Topics |
- Adult
- Asthenopia
(drug therapy)
- Digitalis Glycosides
(adverse effects, therapeutic use)
- Esculin
(adverse effects, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Ophthalmic Solutions
(adverse effects, therapeutic use)
- Phytotherapy
- Refractive Errors
(drug therapy)
- Visual Acuity
- Young Adult
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