[The influence of human immunodeficiency virus co-infection with hepatitis C virus and hepatitis B virus on the efficacy of high active anti-retroviral therapy].

Abstract

OBJECTIVE:

To evaluate the impact of HIV co-infection with HCV or HBV on the efficacy of highly active anti-retroviral therapy (HARRT).

METHODS:

The patients were divided into three groups: HIV + HBV + HCV co-infection group (23 patients), HIV + HCV co-infection group (166 patients), and HIV-only group (178 patients). HIV RNA, HCV RNA or HBV DNA were detected by real time PCR before treatment and 1, 3, 6, 9 and 12 months after treatment, meanwhile the counts of CD(4)(+) T lymphocyte and liver function including ALT, AST and TBil were tested.

RESULTS:

During one-year HAART, HIV RNA of HIV-only group, HIV + HBV + HCV co-infection group and HIV + HCV co-infection group decreased significantly from (6.78 ± 1.08), (6.23 ± 1.34), (6.54 ± 1.23) lg copies/ml to (0.53 ± 0.15), (0.67 ± 0.16), (0.43 ± 0.11) lg copies/ml respectively (P < 0.001). And CD(4)(+) T lymphocyte counts of the three groups elevated significantly from (197 ± 127), (184 ± 113), (213 ± 143) cells/µl to (382 ± 74), (383 ± 70), (378 ± 76) cells/µl respectively (P < 0.001). However there were no differences among the three groups in HIV RNA and CD(4)(+) T lymphocyte counts. There were no differences in liver functions including ALT, AST and TBil among the three groups.

CONCLUSIONS:

HIV co-infected with HBV and/or HCV does not impact on the efficacy of HAART. What more, HAART does not impact HCV replication.

• Authors: Xiao-fei Li, Quan-cheng Kan, Yun He, Zu-jiang Yu, Zhi-qin Li, Hong-xia Liang
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 49 Issue 11 Pg. 951-4 (Nov 2010) ISSN: 0578-1426 [Print] China
• PMID: 21211210 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Antiretroviral Therapy, Highly Active
• Coinfection (drug therapy, virology)
• HIV
• HIV Infections (drug therapy, virology)
• Hepacivirus
• Hepatitis B (drug therapy)
• Hepatitis B virus
• Hepatitis C (drug therapy)
• Humans
• Treatment Outcome