Abstract | BACKGROUND: METHODS: 2 NC children received IVIG 1 g/kg/day in 2 days/month, 5 times, at 3 and 6 months disease duration, respectively. CSF and serum were analysed for hypocretin neuron autoantibodies. An association between disease duration and IVIG effect was calculated in all published NC cases. RESULTS: CONCLUSION:
IVIG treatment initiated before 9 months disease duration has some clinical efficiency. The unaffected CSF hypocretin-1 levels and lack of autoantibodies suggest that any autoimmune process occurs very early in NC. The final IVIG effect needs to be investigated in a placebo-controlled study.
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Authors | S Knudsen, J D Mikkelsen, B Bang, S Gammeltoft, P J Jennum |
Journal | Neuropediatrics
(Neuropediatrics)
Vol. 41
Issue 5
Pg. 217-22
(Oct 2010)
ISSN: 1439-1899 [Electronic] Germany |
PMID | 21210337
(Publication Type: Journal Article)
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Copyright | © Georg Thieme Verlag KG Stuttgart · New York. |
Chemical References |
- Autoantibodies
- HCRT protein, human
- Immunoglobulins, Intravenous
- Intracellular Signaling Peptides and Proteins
- Neuropeptides
- Orexins
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Topics |
- Adolescent
- Autoantibodies
(immunology)
- Child
- Female
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Intracellular Signaling Peptides and Proteins
(immunology)
- Male
- Narcolepsy
(diagnosis, immunology, therapy)
- Neurons
(immunology)
- Neuropeptides
(immunology)
- Orexins
- Sleep
(immunology)
- Surveys and Questionnaires
- Treatment Outcome
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