[Congenital malformations--a systematic cohort study from Mecklenburg-Western Pomerania (Germany)].

Abstract

AIM:

We aimed to set-up a passive malformations registry for 2002-2004 for the German Federal State of Mecklenburg-Western Pomerania in order to estimate the prevalence of congenital malformations among live births, stillbirths, miscarriages, and induced abortions. POPULATION AND STUDY DESIGN: Under the guidance of the working group "Neonatology Mecklenburg-Vorpommern" a standardised malformations record form modelled after the Mainz registry was developed and used to record malformations among live births, stillbirths, miscarriages, and induced abortions in all 21 obstetric departments in Mecklenburg-Western Pomerania between 2002 and 2004. We compared the population of neonates with malformations with a general population sample from the German Perinatal Survey of 1995-1997.

RESULTS:

There were 768 neonates with at least one major malformation among a total of 37 634 neonates in Mecklenburg-Western Pomerania; this means that the prevalence of major malformations was 203.53 per 10 000 neonates. The prevalence of major malformations in liveborn infants was 178.61 per 10 000. The most common malformations in the total study population were ventricular septal defect (prevalence: 37.2 per 10 000), hydronephrosis (16.7 per 10 000), hypospadias (14.8 per 10 000), Down syndrome (10.1 per 10 000), and cleft lip and palate (9.0 per 10 000). Among the induced abortions the most common diagnoses were Down syndrome, anencephalus, Edwards syndrome, and congenital hydrocephalus. The preterm birth rate among the 637 liveborn and stillborn infants with malformations was 19.6%; 5.6% were born before 32 completed weeks of gestation. The small for gestational age rate for infants with malformations was 14.2% for girls and 14.5% for boys, thus increased compared with the general population sample (9.7%).

CONCLUSIONS:

Congenital malformations are important determinants of childhood morbidity and mortality. Malformation prevalence and types of malformations, along with morbidity and mortality, are important parameters in perinatal medicine. The establishment of active malformation registries is therefore an important task.

• Authors: D Olbertz, M Voigt, S Straube, I Renz, V Steinbicker, S Pötzsch, V Briese
• Journal: Zeitschrift fur Geburtshilfe und Neonatologie (Z Geburtshilfe Neonatol) Vol. 214 Issue 6 Pg. 243-8 (Dec 2010) ISSN: 1439-1651 [Electronic] Germany
• Vernacular Title: Angeborene Fehlbildungen - eine systematische Kohortenstudie aus Mecklenburg-Vorpommern.
• PMID: 21207325 (Publication Type: English Abstract, Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Topics

• Abortion, Induced (statistics & numerical data)
• Abortion, Spontaneous (epidemiology)
• Cohort Studies
• Congenital Abnormalities (mortality)
• Female
• Germany (epidemiology)
• Humans
• Infant, Newborn
• Live Birth (epidemiology)
• Male
• Registries (statistics & numerical data)
• Risk Assessment
• Risk Factors
• Stillbirth (epidemiology)