[A case report of hemolytic uremic syndrome (HUS) induced by antineoplastic agents].

Abstract

An autopsy case of hemolytic uremic syndrome after treatment with antineoplastic agents for advanced gastric carcinoma is reported. A 70 year-old woman underwent partial gastrectomy for gastric carcinoma on April 16, 1987 (P0H0S2N4, Stage IV). She was treated with Mitomycin C (MMC), UFT, OK-432 and PSK as post operative chemotherapy. Total doses were 60 mg of MMC, 33.9 g of UFT, 55 KE of OK-432 and (507 g) of PSK. She suffered from occult blood in urine in September 1987, thrombocytopenia and anemia in October, edema and hypertension in November and died due to acute renal failure and pulmonary failure on December 5, 1987. It seemed that the cause of death was hemolytic uremic syndrome induced by antineoplastic agents.

• Authors: H Anai, Y Okada, K Okubo, D Korenaga, Y Maehara, K Sugimachi, Y Ohi
• Journal: Nihon Gan Chiryo Gakkai shi (Nihon Gan Chiryo Gakkai Shi) Vol. 25 Issue 7 Pg. 1487-91 (Jul 20 1990) ISSN: 0021-4671 [Print] Japan
• PMID: 2120375 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mitomycins
• Proteoglycans
• Tegafur
• Picibanil
• polysaccharide-K
• Mitomycin
• Uracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Female
• Hemolytic-Uremic Syndrome (chemically induced)
• Humans
• Mitomycin
• Mitomycins (administration & dosage, adverse effects)
• Picibanil (administration & dosage, adverse effects)
• Proteoglycans (administration & dosage, adverse effects)
• Stomach Neoplasms (drug therapy)
• Tegafur (administration & dosage, adverse effects)
• Uracil (administration & dosage, adverse effects)