Abstract |
One hundred and one patients received oral ciprofloxacin prior to elective cataract removal. The quinolone content of the aqueous humour ranged from 2.7% to 15.4% of the corresponding serum level. The mean aqueous peak exceeded 0.4 mg/l between 2 and 3.5 h after administration. The highest aqueous concentration was achieved with a 1 g dose. In uninflamed eyes oral ciprofloxacin achieved intraocular concentrations that are bactericidal for Gram-negative bacteria including Pseudomonas aeruginosa. It may prove useful in the treatment of established intraocular infection and in prophylaxis prior to silastic implants.
|
Authors | G Sweeney, A I Fern, G Lindsay, M W Doig |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 26
Issue 1
Pg. 99-105
(Jul 1990)
ISSN: 0305-7453 [Print] England |
PMID | 2120173
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Aqueous Humor
(metabolism)
- Ciprofloxacin
(pharmacokinetics)
- Female
- Humans
- Male
- Middle Aged
- Pseudomonas aeruginosa
(drug effects)
|