Letter: Localized cutaneous reaction to intramuscular vitamin K in a patient with acute fatty liver of pregnancy.

Abstract

Vitamin K1 is frequently used in the treatment and prevention of hypoprothrombinemia and hemorrhagic disease of the newborn. It also serves as an antidote to anticoagulants. Erythematous, indurated, pruritic plaques uncommonly occur in adults after intramuscular injection with vitamin K1. We present a case of a localized cutaneous reaction to intramuscular vitamin K1 in a peripartum patient with acute fatty liver of pregnancy. The history and clinical presentation of our case is presented with a discussion of the pathogenesis pathogenesis of vitamin K1 and available treatment for this condition.

• Authors: Tatiana Sousa, Lindsey Hunter, Matthew Petitt, Michael George Wilkerson
• Journal: Dermatology online journal (Dermatol Online J) Vol. 16 Issue 12 Pg. 16 (Dec 15 2010) ISSN: 1087-2108 [Electronic] United States
• PMID: 21199642 (Publication Type: Case Reports, Letter)

Chemical References

• Vitamin K 1

Topics

• Acute Disease
• Drug Eruptions (etiology)
• Drug Hypersensitivity (etiology)
• Eczema (chemically induced)
• Erythema (chemically induced)
• Fatty Liver (complications)
• Female
• Humans
• Hypoprothrombinemias (drug therapy, etiology)
• Injections, Intramuscular
• Pregnancy
• Pregnancy Complications (drug therapy)
• Puerperal Disorders (etiology)
• Vitamin K 1 (administration & dosage, adverse effects)
• Young Adult