Abstract |
Aegle marmelos is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. In the present study, cancer chemopreventive properties were evaluated on 7, 12-dimethylbenz (a) anthracene (DMBA) induced skin papillomagenesis in Swiss albino mice. A single topical application of DMBA, followed 2 weeks later by repeated application of croton oil till the end of the experiment ( i.e. 16 weeks) caused a 100% tumor incidence. In contrast, mice treated with the AME (50 mg/kg b. wt./animal/day) in the peri-initiational phase (i.e. 7 days before and 7 days after DMBA application; Group IV) and post-initiational phase (from the day of croton oil treatment till the end of the experiment; Group V), exhibited a significant reduction to 70 and 50% respectively. The cumulative number of papillomas after 16 weeks was 67 in the control group, but 26 and 23 in the animals treated with AME at peri-initiational and post-initiational stages, respectively. The tumor burden and tumor yield were significantly decreased (Group IV-3.7, 2.6; Group V- 4.6, 2.3) as compared to carcinogen treated control group (6.7, 6.7). The present study demonstrates the chemopreventive potential of Aegle marmelos fruit extract on DMBA induced skin tumorigenesis in mice.
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Authors | Annapurna Agrawal, Preeti Verma, P K Goyal |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 11
Issue 5
Pg. 1311-4
( 2010)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 21198283
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Plant Extracts
- Plant Preparations
- 9,10-Dimethyl-1,2-benzanthracene
- Croton Oil
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Topics |
- 9,10-Dimethyl-1,2-benzanthracene
(pharmacology)
- Aegle
- Animals
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Cell Transformation, Neoplastic
(chemically induced)
- Chemoprevention
- Croton Oil
(pharmacology)
- Medicine, Ayurvedic
- Mice
- Phytotherapy
- Plant Extracts
(pharmacology)
- Plant Preparations
- Skin
(drug effects, pathology)
- Skin Neoplasms
(chemically induced, drug therapy, prevention & control)
- Tumor Burden
(drug effects)
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