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Changes of very low-density lipoprotein concentration in hepatic blood from cows with fasting-induced hepatic lipidosis.

Abstract
The purpose of this study was to evaluate changes of very low-density lipoprotein (VLDL) components in hepatic blood (HB) from 5 nonlactating nonpregnant cows fasted from days 0 to 3 and subsequently refed to day 10 and, in addition, to assess those of other lipoproteins. Increased phospholipid concentrations in each lipoprotein after the start of fasting suggested their availability for the surface lipids of lipoproteins. Although the VLDL-triglyceride (TG) concentration in HB from all cows increased on day 1, the value on day 4 became similar to that on day 0. However, the concentration on day 10 was significantly increased. In all cows, the decreased ratio of the VLDL-TG concentration in HB to the non-esterified fatty acids (NEFA) concentration in portal blood (PB) on day 4 appeared to reflect relatively decreased secretion of TG as VLDL by NEFA excessively mobilized to the liver via PB. The markedly increased ratio on day 10 was considered to contribute to the improvement of hepatic lipidosis.
AuthorsShin Oikawa, Yuko Mizunuma, Yukari Iwasaki, Mohamed Tharwat
JournalCanadian journal of veterinary research = Revue canadienne de recherche veterinaire (Can J Vet Res) Vol. 74 Issue 4 Pg. 317-20 (Oct 2010) ISSN: 1928-9022 [Electronic] Canada
PMID21197233 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fatty Acids, Nonesterified
  • Lipoproteins, VLDL
  • Triglycerides
  • very low density lipoprotein triglyceride
Topics
  • Animals
  • Cattle
  • Cattle Diseases (blood)
  • Fatty Acids, Nonesterified (blood)
  • Fatty Liver (blood, veterinary)
  • Female
  • Lipidoses (blood, veterinary)
  • Lipoproteins, VLDL (blood)
  • Triglycerides (blood)

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