Selected human leukocyte antigen class II polymorphisms and risk of adult glioma.

Abstract

Few studies have examined the relationship between human leukocyte antigen (HLA) polymorphisms and adult glioma, particularly at class II loci. We evaluated the association between selected HLA class II polymorphisms and adult glioma in a large, hospital-based case-control study, using unconditional logistic regression. DQB1 06 (OR=1.67, 95% CI=1.17-2.39) and DRB1 13 (OR=1.69, 95% CI=1.08-2.64) alleles were associated with an increased risk of glioma, while the DQB1 05 allele showed an inverse association (OR=0.63, 95% CI=0.43-0.93). These results, which were of borderline significance once controlled for the false discovery rate, suggest a potential role for the DQB1 06, DQB1 05, and DRB1 13 alleles in glioma susceptibility.

• Authors: Bryan A Bassig, Peter D Inskip, Laurie Burdette, William R Shapiro, Robert G Selker, Howard A Fine, Jay S Loeffler, Peter M Black, Robert Dubrow, Alina V Brenner
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 233 Issue 1-2 Pg. 185-91 (Apr 2011) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 21195488 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
• Copyright: Copyright © 2010. Published by Elsevier B.V.

Chemical References

• HLA-DQ Antigens
• HLA-DQ beta-Chains
• HLA-DQB1 antigen
• HLA-DR Antigens
• HLA-DRB1 Chains

Topics

• Adult
• Aged
• Brain Neoplasms (genetics, immunology)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease (genetics)
• Glioma (genetics, immunology)
• HLA-DQ Antigens (genetics)
• HLA-DQ beta-Chains
• HLA-DR Antigens (genetics)
• HLA-DRB1 Chains
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic (genetics, immunology)