Reversible electrocardiogram changes and cardiomyopathy secondary to baclofen withdrawal syndrome.

Abstract

Baclofen withdrawal syndrome is a rare and potentially life-threatening condition manifesting with autonomic dysreflexia, high fevers, spasticity, seizures, and multiorgan failure. Reversible cardiomyopathy due to this condition is extremely rare. A high level of suspicion is needed to recognize this condition and start an early intervention to improve patient outcome. Electrocardiographic ST-segment elevation in lead aVR was previously described in association with left main, left anterior descending, and triple-vessel coronary artery disease as well as Takotsubo cardiomyopathy. In this article we present a rare case of reversible cardiomyopathy due to baclofen withdrawal syndrome associated with diffuse ST-segment depressions and ST-segment elevation in lead aVR.

• Authors: Dmitriy Kireyev, Kian-Keong Poh
• Journal: The American heart hospital journal (Am Heart Hosp J) Vol. 8 Issue 1 Pg. 52-4 ( 2010) ISSN: 1751-7168 [Electronic] England
• PMID: 21194052 (Publication Type: Case Reports, Journal Article)

Chemical References

• GABA-B Receptor Agonists
• Muscle Relaxants, Central
• Baclofen

Topics

• Adult
• Autonomic Dysreflexia
• Baclofen (adverse effects, pharmacology, therapeutic use)
• Bundle-Branch Block (chemically induced)
• Electrocardiography (instrumentation, methods)
• Fever
• GABA-B Receptor Agonists (adverse effects, pharmacology, therapeutic use)
• Humans
• Male
• Muscle Relaxants, Central (adverse effects, pharmacology, therapeutic use)
• Muscle Spasticity (drug therapy)
• Substance Withdrawal Syndrome
• Syndrome
• Tachycardia, Sinus (chemically induced)
• Takotsubo Cardiomyopathy (chemically induced)