The thermal injury leads to increasing level of intracellular reactive
oxygen specimen (ROS) reducing the
antioxidant defense system. This pathway has been associated with endothelial and microvascular dysfunction and finally with multiple organ dysfunction (MOD). The purpose of this prospective, randomized clinical study was to determine the
oxidant-
antioxidant balance and investigate the effects of
antioxidant therapy (
cytoflavin) in
burns patients with toxic and post-
hypoxic encephalopathy. The study included 60 patients with thermal
trauma and
encephalopathy. Thirty patients received standard intensive
therapy and
cytoflavin intravenously in dose 10 ml/day 24 h after
trauma during 5 days and 30 patients of the control group received standard intensive
therapy for
burns. Both groups exhibited a high
lipid peroxydation (LPO) (
malondialdehyde, conjugate trienes) and low levels of the
antioxidant defense system,
vitamins A and E on the second day after
trauma. On the 14th day of treatment, the level of LPO (p<0,01) and total MOD (p<0,05) index were significantly lower and MMSE scores were higher (p<0,01) compared to the control group. In conclusion,
cytoflavin, due to its systemic and metabolic effects, was effective in the treatment of post-
hypoxic encephalopathy after the thermal injury.