[Transcatheter intra-arterial injection of combination drugs in case of advanced uterine cervical cancer].

Abstract

A total of 10 uterine cervical cancer patients (stage IIb 2, stage IIIb 6, stage IVb 2) were treated two times with selective intra-arterial injection of combined drugs of CDDP, ADR, 5-FU, MMC before operation or radiation therapy. In all patients, the tumor size was reduced macroscopically as well as on MR images. The tumor marker SCC was decreased after TAI. In 7 cases (IIb 2, IIIb 4, IVb 1) surgical treatment was made about 1 month after TAI. Histological examinations revealed that the cancer invasion markedly reduced and no malignant cells found in 3 patients.

• Authors: Y Kinashi, Y Nagata, M Abe, T Honda, I Takai, S Tai, T Mori
• Journal: Nihon Gan Chiryo Gakkai shi (Nihon Gan Chiryo Gakkai Shi) Vol. 25 Issue 5 Pg. 946-51 (May 20 1990) ISSN: 0021-4671 [Print] Japan
• PMID: 2118163 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Mitomycins
• Mitomycin
• Doxorubicin
• Cisplatin

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, pathology)
• Cisplatin (administration & dosage)
• Doxorubicin (administration & dosage)
• Female
• Humans
• Injections, Intra-Arterial
• Magnetic Resonance Imaging
• Middle Aged
• Mitomycin
• Mitomycins (administration & dosage)
• Uterine Cervical Neoplasms (drug therapy, pathology)