[The research on monoamine neurotransmitters changes in plasma and cerebrospinal fluid in patients with persistent vegetative state].

Abstract

AIM:

To study the relationships between the pathogenesis of persistent vegetative state (PVS) and the levels of monoamine neurotransmitters in plasmas and cerebrospinal fluids (CSFs) in patients with PVS.

METHODS:

The high-pressure liquid chromatography (HPLC) was used to detect.

RESULTS:

It was found that the level of dopamine (1.95 +/- 0.99) was significantly increased in plasma compared with the control (1.16 +/- 0.47) (P < 0.05), but the levels of 5-HT, TYR, TRP, GABA of plasma were insignificantly changed. In cerebrospinal fluid, the level of DA was insignificantly changed, and the level of 5-HT (0.49 +/- 0.32) was significantly decreased compared with the control (1.02 +/- 0.35) (P < 0.05), but the levels of TYR (1.36 +/- 0.11), TRP (0.63 +/- 0.40), GABA (1.15 +/- 0.61) were significantly increased respectively compared with the controls (0.40 +/- 0.24; 0.29 +/- 0.22; 0.37 +/- 0.45) (P < 0.05; P < 0.05; P < 0.01). The levels of GABA and DA in plasma were significant correlated (P < 0.05), and GABA and DA in CSF were also significant correlated (P < 0.01).

CONCLUSION:

The results of this study suggested that PVS is related to the decrease of 5-HT in CSF and the increase of DA in plasma.

• Authors: Xue-Fang Hu, Pei-Dong Wang, De-Gon Yang
• Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 18 Issue 2 Pg. 136-8 (May 2002) ISSN: 1000-6834 [Print] China
• PMID: 21179797 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Biogenic Monoamines

Topics

• Adolescent
• Adult
• Biogenic Monoamines (blood, cerebrospinal fluid)
• Case-Control Studies
• Female
• Humans
• Male
• Middle Aged
• Persistent Vegetative State (blood, cerebrospinal fluid)
• Young Adult