Abstract | BACKGROUND/AIMS: METHODS: RESULTS: Twenty-nine patients had elevated serum GL3 levels. The α-GaL A activity was determined for the 26 patients with high GL3 levels. The mean α-GaL A activity was 64.6 nmol/hr/mg (reference range, 45 to 85), and no patient was identified with decreased α-GaL A activity. Among the group with high GL3 levels, 15 women had a α-GaL A genetics analysis. No point mutations were discovered among the women with high GL3 levels. No correlation was observed between serum GL3 levels and α-GaL A activity; the Pearson correlation coefficient was 0.01352 (p = 0.9478). No significant correlation was observed between increased GL3 levels and the frequency of cardiovascular disease or cerebrovascular disease. CONCLUSIONS:
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Authors | Jeong-Yup Kim, Young-Youl Hyun, Ji-Eun Lee, Hye-Ran Yoon, Gu-Hwan Kim, Han-Wook Yoo, Seong-Tae Cho, No-Won Chun, Byoung-Chunn Jeoung, Hwa-Jung Kim, Keong-Wook Kim, Seong-Nam Kim, Yung-A Kim, Hyun-Ah Lee, Jong-Young Lee, Yung-Chun Lee, Hun-Kwan Lim, Keong-Sik Oh, Seong-Hwan Son, Beong-Hee Yu, Kyeong-So Wee, Eun-Jong Lee, Young-Ki Lee, Jung-Woo Noh, Seung-Jung Kim, Kyu-Bok Choi, Suk-Hee Yu, Heui-Jung Pyo, Young-Joo Kwon |
Journal | The Korean journal of internal medicine
(Korean J Intern Med)
Vol. 25
Issue 4
Pg. 415-21
(Dec 2010)
ISSN: 1226-3303 [Print] Korea (South) |
PMID | 21179280
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Trihexosylceramides
- globotriaosylceramide
- alpha-Galactosidase
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Topics |
- Adult
- Aged
- Fabry Disease
(blood, diagnosis)
- Female
- Humans
- Kidney Failure, Chronic
(blood, therapy)
- Male
- Middle Aged
- Renal Dialysis
- Trihexosylceramides
(blood)
- alpha-Galactosidase
(genetics, metabolism)
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