Abstract |
The prototype cysteinyl leukotriene receptor antagonist, montelukast, is generally considered to have a niche application in the therapy of exercise- and aspirin-induced asthma. It is also used as add-on therapy in patients whose asthma is poorly controlled with inhaled corticosteroid monotherapy, or with the combination of a long-acting beta(2)-agonist and an inhaled corticosteroid. Recently, however, montelukast has been reported to possess secondary anti-inflammatory properties, apparently unrelated to conventional antagonism of cysteinyl leukotriene receptors. These novel activities enable montelukast to target eosinophils, monocytes, and, in particular, the corticosteroid-insensitive neutrophil, suggesting that this agent may have a broader spectrum of anti-inflammatory activities than originally thought. If so, montelukast is potentially useful in the chemotherapy of intermittent asthma, chronic obstructive pulmonary disease, cystic fibrosis, and viral bronchiolitis, which, to a large extent, involve airway epithelial cell/neutrophil interactions. The primary objective of this mini-review is to present evidence for the cysteinyl leukotriene-independent mechanisms of action of montelukast and their potential clinical relevance.
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Authors | Gregory R Tintinger, Charles Feldman, Annette J Theron, Ronald Anderson |
Journal | TheScientificWorldJournal
(ScientificWorldJournal)
Vol. 10
Pg. 2403-13
(Dec 14 2010)
ISSN: 1537-744X [Electronic] United States |
PMID | 21170491
(Publication Type: Journal Article, Review)
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Chemical References |
- Acetates
- Anti-Asthmatic Agents
- Anti-Inflammatory Agents
- Cyclopropanes
- Leukotriene Antagonists
- Quinolines
- Receptors, Leukotriene
- Sulfides
- leukotriene D4 receptor
- montelukast
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Topics |
- Acetates
(pharmacology, therapeutic use)
- Anti-Asthmatic Agents
(pharmacology, therapeutic use)
- Anti-Inflammatory Agents
(pharmacology, therapeutic use)
- Asthma
(drug therapy)
- Cyclopropanes
- Humans
- Leukotriene Antagonists
(pharmacology, therapeutic use)
- Neutrophils
(drug effects, metabolism)
- Pulmonary Disease, Chronic Obstructive
(drug therapy)
- Quinolines
(pharmacology, therapeutic use)
- Receptors, Leukotriene
(metabolism)
- Sulfides
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