Abstract |
The management of patients with refractory immune thrombocytopenic purpura ( ITP) may be difficult. We describe a rapid-onset very long-term remission (9 years) induced by short-term rituximab monotherapy in a 62-year-old man with treatment-refractory chronic ITP. Over a 30-year period from the original diagnosis to last follow-up, the patient needed renewed treatment twelve times within the first two decades and was subsequently brought in continuous complete remission for the last decade by a single course of rituximab. The effect of rituximab in ITP has previously been described. However, in chronic, treatment-refractory ITP occurring in elderly patients, remission rates tend to be low and of short duration.
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Authors | Michael R Clausen, Erik Segel, Margrethe Brandsborg, Francesco d'Amore |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 86
Issue 3
Pg. 256-9
(Mar 2011)
ISSN: 1600-0609 [Electronic] England |
PMID | 21166717
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- Antibodies, Monoclonal, Murine-Derived
- Immunosuppressive Agents
- Rituximab
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Topics |
- Antibodies, Monoclonal, Murine-Derived
(administration & dosage, therapeutic use)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Male
- Middle Aged
- Platelet Count
- Purpura, Thrombocytopenic, Idiopathic
(blood, immunology, therapy)
- Remission Induction
- Rituximab
- Self Tolerance
- Splenectomy
- Time Factors
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