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Efficacy of various single-dose regimens of ceftriaxone in uncomplicated acute gonococcal urethritis in adult males.

Abstract
The therapeutic efficacy of single intramuscular doses of ceftriaxone (Rocephin; Roche) (62.5, 125 and 250 mg), administered without probenecid, was evaluated in 167 adult males with uncomplicated acute gonococcal urethritis. Cure rates of 100% were achieved at 62.5 mg and 250 mg. In the 125 mg dose group, Neisseria gonorrhoeae was isolated from 1 patient at follow-up after therapy. Reinfection was suspected, since this patient returned on day 10 and admitted to sexual contact 2 days previously. Side-effects were minimal, and patient acceptance was better for ceftriaxone dissolved in lignocaine than in sterile water. Chlamydia trachomatis was detected at follow-up in 14.4% patients, confirming that ceftriaxone has no significant effect on chlamydial infection and additional treatment is necessary for patients with coexistent infection.
AuthorsA A Hoosen, N O'Farrell, K D Coetzee, J van den Ende
JournalSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 78 Issue 4 Pg. 187-9 (Aug 18 1990) ISSN: 0256-9574 [Print] South Africa
PMID2116670 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ceftriaxone
Topics
  • Acute Disease
  • Adolescent
  • Adult
  • Ceftriaxone (administration & dosage)
  • Chlamydia trachomatis (isolation & purification)
  • Evaluation Studies as Topic
  • Gonorrhea (drug therapy)
  • Humans
  • Injections, Intramuscular
  • Male
  • Neisseria gonorrhoeae (isolation & purification)
  • Ureaplasma (isolation & purification)
  • Urethritis (drug therapy)

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