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Evaluation of destructive and reparative processes in the liver in experimental chronic granulomatosis of mixed (silicotic and tuberculous) etiology.

Abstract
Experimental silicosis and silicotuberculosis induced by intravenous injection of silicon dioxide particles are characterized by extensive degenerative and necrotic processes in the liver parenchyma. After 6 months, fibrosis of portal tracts in silicotuberculosis and silicosis was 2.8- and 1.4-fold more pronounced that in BCG granulomatosis and silicosis, respectively. Depression of cellular and intracellular regeneration processes in the liver parenchyma was also observed.
AuthorsV A Skurupiy, A P Nadeev, M A Karpov
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 149 Issue 6 Pg. 685-8 (Nov 2010) ISSN: 1573-8221 [Electronic] United States
PMID21165418 (Publication Type: Journal Article)
Topics
  • Animals
  • Chronic Disease
  • Granuloma (etiology)
  • Liver (pathology)
  • Male
  • Mice
  • Mice, Inbred CBA
  • Silicosis (complications, pathology)
  • Tuberculosis (complications, pathology)

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