Abstract | BACKGROUND: METHODS: We evaluated the relationship of plasma GDF-15 concentrations with parameters of obesity, inflammation, and glucose and lipid metabolism in a cohort of 118 morbidly obese patients [mean (SD) age 37.2 (12) years, 89 females, 29 males] and 30 age- and sex-matched healthy lean individuals. All study participants underwent a 75-g oral glucose tolerance test; 28 patients were studied before and 1 year after Roux-en-Y gastric bypass surgery. RESULTS: Obese individuals displayed increased plasma GDF-15 concentrations (P < 0.001), with highest concentrations observed in patients with type 2 diabetes. GDF-15 was positively correlated with age, waist-to-height ratio, mean arterial blood pressure, triglycerides, creatinine, glucose, insulin, C-peptide, hemoglobin A(1c), and homeostatic model assessment insulin resistance index and negatively correlated with oral glucose insulin sensitivity. Age, homeostatic model assessment index, oral glucose insulin sensitivity, and creatinine were independent predictors of GDF-15 concentrations. Roux-en-Y gastric bypass led to a significant reduction in weight, leptin, insulin, and insulin resistance, but further increased GDF-15 concentrations (P < 0.001). CONCLUSIONS:
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Authors | Greisa Vila, Michaela Riedl, Christian Anderwald, Michael Resl, Ammon Handisurya, Martin Clodi, Gerhard Prager, Bernhard Ludvik, Michael Krebs, Anton Luger |
Journal | Clinical chemistry
(Clin Chem)
Vol. 57
Issue 2
Pg. 309-16
(Feb 2011)
ISSN: 1530-8561 [Electronic] England |
PMID | 21164037
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Growth Differentiation Factor 15
- Creatinine
- Glucose
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Topics |
- Adult
- Biomarkers
(blood)
- Blood Pressure
- Body Weights and Measures
- Cardiovascular System
(metabolism)
- Creatinine
(blood)
- Diabetes Mellitus, Type 2
(blood, complications)
- Female
- Gastric Bypass
- Glucose
(metabolism)
- Growth Differentiation Factor 15
(blood)
- Humans
- Inflammation
(blood)
- Insulin Resistance
- Kidney Function Tests
- Lipid Metabolism
- Male
- Obesity, Morbid
(blood, complications, surgery)
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