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[Salt appetite, cramps and palpitations in a 21-year old medical secretary].

Abstract
Hypokalemia is a common finding. The clinical presentation can be paralyses and cardiac arrhythmias. We present a normotensive young woman with salt appetite, cramps and palpitations. In our case report the patient shows a positive family history for hypopotassemia, a metabolic alkalosis with hypotension, and hypocalciuria with an increased urinary potassium loss. The levels of renin and aldosterone were elevated. After a negative testing for metabolites of diuretics, we obtained a positive result of the suspected SLC12A3 genetic test. This mutation leads to a failure of the thiazide-sensitive sodium-2-chloride-cotransporter, the so called Gitelman syndrome, which presents similar to a chronic thiazide therapy. The Gitelman syndrome is a rare disease with renal potassium loss and hypotension. Especially in young patients around the age of twenty or in patients with chronic intractable hypopotassemia a Gitelman syndrome should be considered.
AuthorsD Kitterer, N Braun, M D Alscher, M Kimmel
JournalDer Internist (Internist (Berl)) Vol. 52 Issue 10 Pg. 1238-42 (Oct 2011) ISSN: 1432-1289 [Electronic] Germany
Vernacular TitleSalzhunger, Krämpfe und Palpitationen bei einer 21-jährigen Arzthelferin.
PMID21161146 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Receptors, Drug
  • SLC12A3 protein, human
  • Sodium Chloride, Dietary
  • Solute Carrier Family 12, Member 3
  • Symporters
Topics
  • Arrhythmias, Cardiac (etiology)
  • Diagnosis, Differential
  • Diseases in Twins (diagnosis, genetics)
  • Female
  • Gitelman Syndrome (diagnosis, genetics)
  • Humans
  • Hypokalemia (diagnosis, genetics)
  • Muscle Cramp (etiology)
  • Receptors, Drug (genetics)
  • Sodium Chloride, Dietary (administration & dosage)
  • Solute Carrier Family 12, Member 3
  • Symporters (genetics)
  • Twins, Monozygotic
  • Young Adult

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