[A case of duodenal perforation during mFOLFOX6 treatment for metastatic sigmoid colon cancer].

Abstract

We present a case of metastatic sigmoid colon cancer causing duodenal perforation during modified FOLFOX6 chemotherapy. The patient was a 68-year-old man who underwent sigmoidectomy for an advanced sigmoid cancer in September 2007. He has been received mFOLFOX6 chemotherapy for multiple liver metastases since January 2009. In March 2010, the patient complained of abdominal pain during the 24th course of chemotherapy, and was admitted to our hospital. On admission, his vital signs were normal, and abdominal findings revealed no peritonitis signs. An abdominal CT scan showed free air and fluid collection on the first day of admission. The patient was diagnosed with gastrointestinal perforation, and underwent emergency operation for abdominal drainage. The leakage of biliary fluids was recognized at the drain to the Winslow postoperatively. It ceased on the 25th admission day, and an upper gastrointestinal examination showed good passage of fluids and no leakage at the duodenum. However, the patient died 36 days after admission from remarkable pleural effusion and respiratory failure.

• Authors: Kazuhiro Sakamoto, Yoshihiko Tashiro, Koichiro Niwa, Seigo Ono, Shun Ishiyama, Kiichi Sugimoto, Hirohiko Kamiyama, Hiromitsu Komiyama, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki, Junji Ichikawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 37 Issue 13 Pg. 2925-7 (Dec 2010) ISSN: 0385-0684 [Print] Japan
• PMID: 21160272 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Organoplatinum Compounds
• Leucovorin
• Fluorouracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Duodenal Diseases (etiology)
• Fluorouracil (therapeutic use)
• Humans
• Intestinal Perforation (etiology)
• Leucovorin (therapeutic use)
• Male
• Organoplatinum Compounds (therapeutic use)
• Sigmoid Neoplasms (complications, drug therapy)