[Clinical guidelines for the diagnosis and treatment of dermatitis herpetiformis].

Abstract

Dermatitis herpetiformis is an autoimmune blistering disease that appears as a cutaneous manifestation of gluten intolerance. It is one of a group of disorders that have gluten sensitivity in common, including celiac disease and gluten ataxia. Patients with dermatitis herpetiformis present with a pruritic papulovesicular rash on extensor surfaces and on the buttocks. Immunological studies demonstrate the presence of specific immunoglobulin (Ig) A anti-endomysial and anti-transglutaminase antibodies. The finding of granular deposits of IgA along the dermal-epidermal junction is pathognomonic of dermatitis herpetiformis. Treatment of dermatitis herpetiformis is based on a life-long, strict gluten-free diet, which improves all clinical aspects of gluten sensitivity, and dapsone, a drug that is only effective for the skin manifestations.

• Authors: J E Herrero-González
• Journal: Actas dermo-sifiliograficas (Actas Dermosifiliogr) Vol. 101 Issue 10 Pg. 820-6 (Dec 2010) ISSN: 1578-2190 [Electronic] Spain
• Vernacular Title: Guía clínica de diagnóstico y tratamiento de la dermatitis herpetiforme.
• PMID: 21159258 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Dermatitis Herpetiformis (diagnosis, drug therapy, immunology)
• Humans
• Practice Guidelines as Topic