[Immunological alterations and selectin values in hypertensive patients treated according to current criteria].

Abstract

BACKGROUND AND OBJECTIVE:

To calculate the relationship of E and P selectins with immunological changes in essential hypertension.

PATIENTS AND METHOD:

We included 261 patients with essential hypertension with or without left ventricular hypertrophy (LVH), in whom selectins and specific cytokines were quantified.

RESULTS:

E-and P-selectins were increased in hypertension compared to controls [75(51) ng/mL versus 45(17) ng/mL, (p<0.0001) and 47(18) ng/mL versus 38(15) ng/mL, (p=0.049), respectively], as well as cytokine concentrations (p<0.0001). Furthermore, selectin values were significantly correlated with changes in immunological markers. The multivariate analysis showed that IL-1ra (p<0.0001) and P-selectin (p=0.013) were independent factors of E-selectin values. For P-selectin, IL-1ra (p=0.005), IL-8 (p<0.0001) and selectin-E (p=0.013) influenced on its concentration. Finally, selectin values were similar between patients with or without left ventricular hypertrophy.

CONCLUSIONS:

Immunological activation influenced on selectin concentrations in cardiologic asymptomatic patients with essential hypertension. LVH did not induce significant changes.

• Authors: Raquel Cortés, Manuel Portolés, Esther Roselló-Lletí, José Ramón González-Juanatey, Vicente Bertomeu, Miguel Rivera
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 137 Issue 6 Pg. 254-6 (Sep 10 2011) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Alteraciones inmunológicas y de los valores de selectinas en pacientes hipertensos tratados según criterios actuales.
• PMID: 21145074 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier España, S.L. All rights reserved.

Chemical References

• Antihypertensive Agents
• Cytokines
• E-Selectin
• P-Selectin

Topics

• Aged
• Antihypertensive Agents (therapeutic use)
• Asymptomatic Diseases
• Comorbidity
• Cross-Sectional Studies
• Cytokines (blood)
• Diabetes Complications (epidemiology)
• Dyslipidemias (epidemiology)
• E-Selectin (blood)
• Female
• Humans
• Hypertension (blood, complications, drug therapy, immunology)
• Hypertrophy, Left Ventricular (blood, etiology, immunology)
• Male
• Middle Aged
• P-Selectin (blood)
• Smoking (epidemiology)