Abstract | BACKGROUND:
Inflammation and pain associated with temporomandibular joint disorder, a chronic disease that affects 15% of the adult population, involves activation of trigeminal ganglion nerves and development of peripheral and central sensitization. Natural products represent an underutilized resource in the pursuit of safe and effective ways to treat chronic inflammatory diseases. The goal of this study was to investigate effects of grape seed extract on neurons and glia in trigeminal ganglia and trigeminal nucleus caudalis in response to persistent temporomandibular joint inflammation. Sprague Dawley rats were pretreated with 200 mg/kg/d MegaNatural-BP grape seed extract for 14 days prior to bilateral injections of complete Freund's adjuvant into the temporomandibular joint capsule. RESULTS: CONCLUSIONS:
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Authors | Ryan J Cady, Jeffery J Hirst, Paul L Durham |
Journal | Molecular pain
(Mol Pain)
Vol. 6
Pg. 91
(Dec 10 2010)
ISSN: 1744-8069 [Electronic] United States |
PMID | 21143976
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Flavonoids
- Phenols
- Polyphenols
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Topics |
- Animals
- Flavonoids
(pharmacology)
- Male
- Neuroglia
(drug effects)
- Neurons
(drug effects)
- Phenols
(pharmacology)
- Polyphenols
- Rats
- Rats, Sprague-Dawley
- Seeds
(chemistry)
- Temporomandibular Joint Disorders
(drug therapy)
- Trigeminal Caudal Nucleus
(cytology)
- Trigeminal Ganglion
(cytology)
- Vitis
(chemistry)
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