Mannose-binding lectin codon 54 gene polymorphism in relation to risk of nosocomial invasive fungal infection in preterm neonates in the neonatal intensive care unit.

Abstract

OBJECTIVE:

Preterm neonates are susceptible to infection due to a combination of sub-optimal immunity and increased exposure to invasive organisms. Invasive fungal infections are associated with significant morbidity and mortality among preterm infants cared for in the neonatal intensive care unit (NICU). Mannose-binding lectin (MBL) is a component of the innate immune system, which may be especially important in the neonatal setting. The objective of this study was to investigate the presence of any association between MBL gene polymorphism and nosocomial invasive fungal infection in preterm neonates.

METHODS:

Codon 54 (B allele) polymorphism in exon 1 of the MBL gene was investigated in 31 patients diagnosed as nosocomial invasive fungal infection and 30 control preterm neonates.

RESULTS:

AB genotype was determined in 26% and 30% of patient and control groups, respectively, and the difference was not statistically significant. AA genotype was determined in 74% of the patient group and in 67% of the control group, and the difference was not statistically significant. B allele frequency was not different significantly in the patient group (13%) compared to the control group (18%).

CONCLUSIONS:

In our study, no relationship was found between MBL codon 54 gene polymorphism and the risk of nosocomial invasive fungal infection in preterm neonates in NICU.

• Authors: Cumhur Aydemir, Huseyin Onay, Serife Suna Oguz, Taha Resid Ozdemir, Omer Erdeve, Ferda Ozkinay, Ugur Dilmen
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 24 Issue 9 Pg. 1124-7 (Sep 2011) ISSN: 1476-4954 [Electronic] England
• PMID: 21142772 (Publication Type: Journal Article)

Chemical References

• Codon
• Mannose-Binding Lectin

Topics

• Candidiasis, Invasive (epidemiology, genetics)
• Codon (genetics)
• Cross Infection (epidemiology, genetics)
• Genetic Predisposition to Disease
• Humans
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (epidemiology, genetics)
• Intensive Care Units, Neonatal (statistics & numerical data)
• Mannose-Binding Lectin (genetics)
• Mycoses (epidemiology, genetics)
• Polymorphism, Genetic (physiology)
• Risk Factors