Beta-adrenergic receptors in cancer: therapeutic implications.

Abstract

The beta-adrenergic receptors transduce catecholamine signals to the G protein, which through a cascade of chemical reactions in cells generates highly specific parallel signals. The beta2-adrenergic receptor (ADRB2) is the most involved in the carcinogenic processes. Previous studies have determined the relationship of ADRB2 with various aspects related to cancer. Basically, it seems to be related with cell proliferation and apoptosis, chemotaxis, development of metastasis and tumor growth, and angiogenesis. The purpose of this review is to update the implications of these receptors in the pathogenesis of cancer and study the possible application of agonist drugs and/or antagonists in antitumor therapy.

• Authors: Mario Pérez-Sayáns, José Manuel Somoza-Martín, Francisco Barros-Angueira, Pilar Gayoso Diz, José Manuel Gándara Rey, Abel García-García
• Journal: Oncology research (Oncol Res) Vol. 19 Issue 1 Pg. 45-54 ( 2010) ISSN: 0965-0407 [Print] United States
• PMID: 21141740 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, Adrenergic, beta

Topics

• Animals
• Apoptosis
• Cell Movement
• Chemotaxis
• Humans
• Neoplasm Metastasis
• Neoplasms (drug therapy, etiology, pathology)
• Receptors, Adrenergic, beta (physiology)