[The reaction of the hypophysis to thyroliberin and metoclopramide in women with hyperprolactinemia].

Abstract

Functional tests with i.v. injection of metoclopramide (10 mg) and thyroliberin (200 micrograms) with a record of PRL and TSH levels for 120 min. were performed in 87 women of reproductive age (19 healthy nonpregnant women, 9 women in the early postnatal period, 10 patients with primary hypothyroidism, and 30 patients with PRL secreting chromophobe adenomas). Hyperprolactinemic anovulation was noted in 35 examinees. Comparison of the results of thyroliberin and metoclopramide tests in different groups of examinees was suggestive of a decrease in dopaminergic inhibition of the hypophysis in postnatal and adenomatous hyperprolactinemia. The presence and a degree of hyperprolactinemia in patients with primary hypothyroidism depends, probably, on the ratio of a stimulating effect of endogenous thyroliberin and inhibitory action of dopamine on hypophyseal lactotrophs.

• Authors: N N Tkachenko, V V Potin, S V Beskrovnyĭ, L G Nosova
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) 1990 Mar-Apr Vol. 36 Issue 2 Pg. 35-40 ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Reaktsiia gipofiza na tiroliberin i metoklopramid u zhenshchin s giperprolaktinemieĭ.
• PMID: 2114023 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Thyrotropin-Releasing Hormone
• Prolactin
• Thyrotropin
• Metoclopramide
• Dopamine

Topics

• Adult
• Dopamine (physiology)
• Female
• Humans
• Hyperprolactinemia (blood, etiology, physiopathology)
• Hypothyroidism (blood, complications, physiopathology)
• Menstrual Cycle (blood, drug effects)
• Metoclopramide
• Pituitary Gland (drug effects, physiology)
• Pituitary Neoplasms (blood, complications, physiopathology)
• Postpartum Period (blood, drug effects)
• Pregnancy
• Prolactin (blood)
• Prolactinoma (blood, complications, physiopathology)
• Thyrotropin (blood)
• Thyrotropin-Releasing Hormone
• Time Factors