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Polyclonal IgM anti-GM1 ganglioside antibody in patients with motor neuron disease and variants.

Abstract
Recent studies reported the presence of anti-ganglioside antibodies in occasional patients with motor neuron disease. We found polyclonal serum IgM anti-GM1 antibodies by an anti-GM1 enzyme-linked immunosorbent assay (ELISA) in 9 (19%) of 48 patients with motor neuron disease. A comparable frequency of IgM anti-GM1 antibodies was found in 4 (10%) of 40 sera from patients with other neurological disease. Three (17%) of 18 sera from the patients with motor neuron disease and 2 (17%) of 12 sera from patients with other neurological diseases had anti-GM1 immunostaining as shown by thin layer chromatography immunoblot. One patient with a lower motor neuron variant of motor neuron disease or motor axonopathy without multifocal conduction block had a markedly elevated polyclonal IgM anti-GM1 ELISA titer (greater than 1:64,000) with prominent immunostaining of GM1, moderate immunostaining of GM2, and weak and inconsistent immunostaining of GD1b by thin layer chromatography immunoblot. Treatment with prednisone resulted in clinical improvement despite increasing anti-GM1 antibody titers. These data indicate that patients with motor neuron disease have measurable levels of anti-ganglioside antibodies as frequently as patients with other neurological diseases. This contrasts with a small subgroup of patients with a lower motor neuron variant of motor neuron disease or motor axonopathy who have markedly elevated levels of serum anti-ganglioside antibodies and a clinical syndrome that is treatable with immunosuppression.
AuthorsE F Salazar-Grueso, M J Routbort, J Martin, G Dawson, R P Roos
JournalAnnals of neurology (Ann Neurol) Vol. 27 Issue 5 Pg. 558-63 (May 1990) ISSN: 0364-5134 [Print] United States
PMID2113790 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Autoantibodies
  • Immunoglobulin mu-Chains
  • G(M1) Ganglioside
Topics
  • Amyotrophic Lateral Sclerosis (immunology)
  • Autoantibodies (metabolism)
  • Female
  • G(M1) Ganglioside (immunology)
  • Humans
  • Immunoglobulin mu-Chains (metabolism)
  • Middle Aged
  • Motor Neurons (immunology)
  • Neuromuscular Diseases (immunology)

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