Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias.

Abstract

BACKGROUND/AIMS:

We determined cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ)(1-38), Aβ(1-40), Aβ(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer's dementia (AD, n = 25) and nondemented controls (n = 20).

METHODS:

Commercially available ELISA and electrochemiluminescence methods were applied.

RESULTS:

High CSF p-tau and low ratios of Aβ(1-42)/Aβ(1-40) and Aβ(1-42)/Aβ(1-38), respectively, were specific for AD. CSF Aβ(1-38) was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD.

CONCLUSION:

This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations.

• Authors: Mirko Bibl, Brit Mollenhauer, Piotr Lewczuk, Hermann Esselmann, Stefanie Wolf, Markus Otto, Johannes Kornhuber, Eckart Rüther, Jens Wiltfang
• Journal: Dementia and geriatric cognitive disorders (Dement Geriatr Cogn Disord) Vol. 31 Issue 1 Pg. 37-44 ( 2011) ISSN: 1421-9824 [Electronic] Switzerland
• PMID: 21135556 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 S. Karger AG, Basel.

Chemical References

• Amyloid beta-Peptides
• Biomarkers
• Peptide Fragments
• amyloid beta-protein (1-38)
• amyloid beta-protein (1-40)
• amyloid beta-protein (1-42)
• tau Proteins

Topics

• Aged
• Alzheimer Disease (cerebrospinal fluid)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Aphasia, Primary Progressive (cerebrospinal fluid, psychology)
• Biomarkers (cerebrospinal fluid)
• Enzyme-Linked Immunosorbent Assay
• Female
• Frontotemporal Dementia (cerebrospinal fluid, psychology)
• Humans
• Luminescence
• Male
• Middle Aged
• Neuropsychological Tests
• Peptide Fragments (cerebrospinal fluid)
• Phenotype
• tau Proteins (cerebrospinal fluid)