HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Renal malakoplakia: an underestimate cause of renal failure].

Abstract
Malakoplakia is an inflammatory granulomatous disease induced by defective phagocytic activity of macrophage. Malakoplakia is histologically characterized by the presence of Michaelis-Gutmann bodies in macrophages. Although not uncommon in the genito-urinary tract, isolated malakoplakia of the kidney is rarely found. Its main clinical presentation associates acute renal failure and acute pyelonephritis. The clue for diagnosis of renal malakoplakia is based on renal biopsy showing Michaelis-Gutmann bodies. Establishing the diagnosis of renal malakoplakia is essential as it determines the choice of antibiotics and duration of treatment. Prognosis remains poor, leading frequently to chronic renal failure. In this paper, we report four cases of renal malakoplakia and discuss clinical presentation, biological and pathological features, treatment and prognosis of this disease.
AuthorsMaïté Daroux, Marie Frimat, Tristan Mirault, Dominique Fleury, Vincent Lemaitre, Laure-Hélène Noel, Philippe Vanhille
JournalNephrologie & therapeutique (Nephrol Ther) Vol. 7 Issue 2 Pg. 111-6 (Apr 2011) ISSN: 1872-9177 [Electronic] France
Vernacular TitleMalacoplakie renale: une cause méconnue d'insuffisance rénale.
PMID21126934 (Publication Type: Case Reports, English Abstract, Journal Article)
CopyrightCopyright © 2010 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.
Chemical References
  • Anti-Bacterial Agents
  • Glucocorticoids
  • Vitamins
  • Ascorbic Acid
Topics
  • Aged
  • Anti-Bacterial Agents (therapeutic use)
  • Ascorbic Acid (therapeutic use)
  • Biopsy
  • Diabetic Nephropathies (complications)
  • Drug Therapy, Combination
  • Fatal Outcome
  • Female
  • Glucocorticoids (therapeutic use)
  • Humans
  • Kidney Diseases (complications, pathology, therapy)
  • Liver Cirrhosis (complications)
  • Macrophages (pathology)
  • Malacoplakia (complications, pathology, therapy)
  • Male
  • Middle Aged
  • Renal Dialysis (methods)
  • Renal Insufficiency (etiology)
  • Risk Factors
  • Treatment Outcome
  • Vitamins (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: