Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement.

Abstract

The purpose of this study is to determine the relationship of ocular adnexal benign or reactive lymphoid hyperplasia, including orbital pseudotumor, with immunoglobulin G4 (IgG4)-related diseases. Medical charts of 9 consecutive patients with ocular adnexal benign lymphoid lesions, seen in the Department of Ophthalmology, Okayama University Hospital, were reviewed, and pathological sections were restained immunohistochemically for IgG4-, IgG-, and CD138-positive plasma cells. The diagnosis of IgG4-positive lesions was based on 10 or more IgG4-positive plasma cells in a high-power field and greater than 40% ratios of IgG4-positive plasma cells/CD138-positive plasma cells and IgG4-positive plasma cells/IgG-positive plasma cells. IgG4-positive lesions were determined as absent in 5 patients (4 with bilateral lacrimal/orbital lesions and one with a unilateral conjunctival lesion), none of whom showed systemic manifestations. In contrast, IgG4-positive lesions were present in 4 patients (3 with bilateral lacrimal/orbital lesions and one with a unilateral lacrimal/orbital lesion), who showed systemic manifestations : one with Hashimoto thyroiditis, one with IgG4-positive bilateral interstitial lung disease and hepatic inflammatory pseudotumor, one with bilateral interstitial lung disease, and one with systemic lymphadenopathy and antiphospholipid syndrome. In conclusion, IgG4-positive ocular adnexal benign lymphoid lesions might be used as a benchmark for the probable presence of other systemic lymphoid lesions.

• Authors: Toshihiko Matsuo, Kouichi Ichimura, Yasuharu Sato, Yasushi Tanimoto, Katsuyuki Kiura, Sou Kanazawa, Toshiaki Okada, Tadashi Yoshino
• Journal: Journal of clinical and experimental hematopathology : JCEH (J Clin Exp Hematop) Vol. 50 Issue 2 Pg. 129-42 ( 2010) ISSN: 1880-9952 [Electronic] Japan
• PMID: 21123971 (Publication Type: Journal Article)

Chemical References

• Immunoglobulin G

Topics

• Adult
• Aged
• Aged, 80 and over
• Antiphospholipid Syndrome (complications)
• Eye Diseases (complications, immunology, pathology)
• Female
• Granuloma, Plasma Cell (complications)
• Hashimoto Disease (complications)
• Humans
• Immunoglobulin G (immunology)
• Immunohistochemistry
• Liver Diseases (complications)
• Lung Diseases, Interstitial (complications)
• Lymphatic Diseases (complications)
• Lymphoproliferative Disorders (complications, immunology, pathology)
• Male
• Middle Aged
• Young Adult